Femara used for Infertility Treatment






The generic drug name for Femara is Letrozole and is used fairly commonly as an infertility treatment drug, although it is not licensed for infertility its use is known as "off-label". It should be noted that it is generally not considered safe for women who are pregnant.

Femara is widely used in post-menopausal women with breast cancer and belongs to a class of medications known as aromatase inhibitors.

Novartis AG (based in Switzerland) is the manufacturer of of this drug, and they have sent a notice to doctors warning that there are reported cases of birth defects that arose in the children of women who received Femara whilst pregnant. Novartis, also reviewed their safety database and found 13 reports of pregnant women receiving the drug worldwide. Of those 13 women, two had children with birth defects. In the United States, the labeling of Femara already warns that it has been associated with birth defects. Novartis has never sought FDA approval to market this drug as a fertility medication and are concerned about their liability if given in pregnancy.

However, there are no reports of it being associated with birth defects when given prior to pregnancy. It is important to make the distinction that when used as a fertility medication, that it is given before the establishment of pregnancy. As a medication it is metabolized rapidly in the body. It is not thought to have significant levels in the blood or tissues for a prolonged period of time.

Aromatase is an enzyme that is responsible for the production of estrogen in the body and Femara works by inhibiting aromatase, suppressing the production of estrogen. Whereas Clomid (Clomiphene citrate), blocks estrogen receptors. In both cases, the result is that the pituitary gland produces more of the hormones needed to stimulate the ovaries. These hormones, FSH and LH, can cause the development of ovulation in women who are anovulatory or increase the number of eggs developing in the ovaries of women who already ovulate. As a result, several studies have now been published using Femara as a fertility drug.

Dose to take:

Nobody has yet identified the optimal dose there are three dose regimens that have been tested: 2.5 mg, 5 mg and 7.5 mg. Different studies comparing these dose regimens have occasionally found favor with one dose or another but there is no conclusive data that one dose is better than another. The usual length of treatment is for five days.

Some early studies suggested that the pregnancy rates with Femara far exceeded those with (clomiphene citrate) Clomid and were possibly even higher than gonadotropins. Further data has determined that this is not the case. Pregnancy rates are similar to those seen with Clomid and are lower than the pregnancy rates seen with gonadotropins. Older patients have a lower chance of success than younger patients. To increase your chances of success. <- Click Here ->

Treatment may still be successful even if other treatments have failed. For example, some data shows that in women who did not ovulate with Clomid (clomiphene citrate), they still may ovulate with Femara.

Side effects:

Femara works on its ability reduce female estrogen levels. Low estrogen levels of any cause can cause woman to have symptoms. The data on side effects comes from women who have been using this drug for an extended period of time in order to treat breast cancer. The treatment duration is only five days. The side effects are similar to those seen with clomiphene citrate (Clomid) include: Hot flashes, Headaches, Breast tenderness, Constipation, depression, alpopecia plus others including vomiting, but your health professional should advise you on the side effects and the incidences of side affects in people and how to manage them. Remember no manufactured drug is side effect free.

Use in Pregnancy:

Studies conducted to-date have shown no increased risk of miscarriage or a decrease in miscarriage risk. This medication should not be given to women who are already pregnant. Studies in rats and mice have shown that it increases the risk of fetal death and malformations. Since there are no studies in human beings, it should be assumed that a similar effect is possible.

When you think about it these drugs put you through a lot although your chances are better see below for treatment protocols, but what are you looking for really " To Get Pregnant Naturally and give birth to a healthy child... Guaranteed! -- Discover how Lisa Olson has taught thousands of women worldwide to conceive faster than they ever thought possible... Even if you've never succeeded to get pregnant before...for all ages... Right here you've found the pregnancy success system you've been looking for!"Click Here --> Alternative to Femara <--

Femara Fertility Treatment Protocol

Monitoring with ovulation predictor kits and having intercourse only.

1. Call the office on Day 1 of your period.
2. Day 2 or 3 - Office visit- Blood test and ultrasound.
3. Take the Letrozole (Femara) 2.5 mg tablet on days 5,6,7,8, and 9.
4. Start testing urine on the morning of day 10 or 11.
5. Look for the first definite color change. Do not continue to test after the color change.
6. Have intercourse the same day you see the color change and the next day.
7. Call the office when you see the color change. Schedule an appointment approximately one week later for a blood test to verify ovulation.

Monitoring with ovulation predictor kits and having an IUI - intrauterine insemination

1. Call the office on Day 1 of your period.
2. Day 2 or 3 - Office visit- Blood test and ultrasound.
3. Take Femara 2.5 mg on days 5,6,7,8, and 9.
4. Start testing urine on the morning of day 10 or 11.
5. Look for the first definite color change. Do not continue to test after the color change.
6. Call the office the same morning you see the color change. Have intercourse that night.
7. Schedule the intrauterine insemination for the next day (The day after the color change)
8. Schedule an appointment approximately one week later for a blood test to verify ovulation
9. Schedule an appointment approximately two weeks later for a pregnancy test

Monitoring in the office with intrauterine insemination or intercourse

1. Call the office on Day 1 of your period.
2. Day 2 or 3 - Office visit- Blood test and ultrasound.
3. Take the Letrozole (Femara) on days 5,6,7,8, and 9.
4. Day 10 or 11 - Office visit - Blood test and ultrasound. You will receive instructions that afternoon when to return for the next visit.
5. Only when instructed – Take the hCG trigger injection in the evening. Have intercourse that evening also.
6. Schedule the insemination for 2 (two) days after the hCG trigger . If you are not doing intrauterine insemination, have intercourse again on this day.
7. 1 week after hCG trigger - Office visit - Blood test only (Progesterone level)
8. 2 weeks after hCG trigger - Office visit - Blood test only (Pregnancy test).